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prognia.

Endocrinology and metabolism

HOMA-IR

2 inputsEndocrinology and metabolism

Homeostatic Model Assessment of Insulin Resistance.

HOMA-IR calculator

Result

1.78

Low-normal insulin sensitivity

2 to 25 mmol/L

1 to 200 µIU/mL

How to use it

  1. 1

    Fasting samples (minimum 8h fast). Serum glucose in mmol/L, insulin in µIU/mL.

  2. 2

    HOMA-IR = (glucose × insulin) / 22.5. Threshold for IR varies by lab and ethnicity: often > 2.5 or > 3.0.

  3. 3

    Limitations. Single time-point; affected by acute illness, corticosteroids, recent food.

When to use it

PCOS evaluation
HOMA-IR > 2.5 in PCOS supports metformin use.
MASLD/NASH risk
HOMA-IR correlates with hepatic fat and fibrosis in metabolic liver disease.
Research
Common surrogate for insulin sensitivity in metabolic trials.

A reference for clinicians and students, not medical advice. A score supports a decision; it does not make one. Check every result against the patient in front of you and your local protocol.

At a glance

Specialty
Endocrinology and metabolism
Inputs
2
Type
Formula

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