Nottingham Prognostic Index calculator
Result
3.4
Prognostic group: Good (<3.4) — 15-year survival ~80%+
How to use it
- 1
NPI = 0.2 × size (cm) + nodal stage + grade. From pathology report.
- 2
Prognostic groups. Good ≤3.4: lowest adjuvant therapy threshold. Poor >5.4: maximum systemic therapy.
- 3
Supplemented by molecular markers. ER/PR/HER2 status and Ki-67, Oncotype DX recurrence score further refine risk.
When to use it
- Adjuvant systemic therapy decision
- NPI used alongside Oncotype DX/Prosigna to guide chemotherapy decision in early breast cancer.
- Patient counselling
- Explains prognosis in terms of tumour biology.
- MDT discussion
- NPI provides objective clinical input alongside molecular profiling.
A reference for clinicians and students, not medical advice. A score supports a decision; it does not make one. Check every result against the patient in front of you and your local protocol.
At a glance
- Specialty
- Oncology
- Inputs
- 3
- Type
- Formula
