Sexual medicine
Clinical phenotypes and multidomain sexual function in men with ejaculatory and orgasmic dysfunction: a cross-sectional analysis of the CLIMAX Registry
By Hariharan L, Perelmuter S, Hill R and 2 others.
Abstract
Introduction
Delayed ejaculation (DE) and anorgasmia/anejaculation are frequently grouped together, yet whether they represent distinct clinical phenotypes or points along a shared spectrum remains unclear. Relationships between erectile function and other sexual function domains have been characterized primarily in men with erectile dysfunction rather than ejaculatory or orgasmic dysfunction. We sought to characterize clinical phenotypes and multidomain sexual function among men with ejaculatory or orgasmic dysfunction using baseline data from the CLIMAX Registry.
Methods
We performed a cross-sectional secondary analysis of baseline data from 43 participants enrolled in the prospective, multi-institutional CLIMAX Registry. The phenotype analysis included isolated DE (n = 14) and isolated anorgasmia/anejaculation (n = 13), defined as selection of these diagnoses without another ejaculatory/orgasmic diagnosis. These groups were compared using clinical, psychosocial, and sexual function characteristics. A separate analysis of the broader registry cohort evaluated relationships between erectile function and other sexual function domains. Participants with complete International Index of Erectile Function erectile function domain (IIEF-EF) scores were stratified by erectile function severity (IIEF-EF ≥17 [none/mild erectile dysfunction] vs IIEF-EF ≤16 [moderate/severe erectile dysfunction]). Continuous variables were compared using Mann-Whitney U tests, categorical variables using Fisher exact tests, and erectile function and orgasmic function were evaluated using Pearson correlation.