Canadian Urological Association journal = Journal de l'Association des urologues du Canada
Does treatment of non-obstructing nephrolithiasis reduce recurrent urinary tract infections? A prospective, observational trial from the EDGE consortium
By Forbes CM, Stern KL, Finegan J and 14 others.
Abstract
Introduction
Existing studies link kidney stone treatment to reduced recurrent urinary tract infections (UTIs); however, these studies are limited by their retrospective design and/or lack of comparison group. The present study assesses a prospective, observational cohort of patients with recurrent UTIs who selected observation or intervention for management of their non-obstructing kidney stones to assess for impact on UTI recurrence.
Methods
From 2020-2025, patients with non-obstructing kidney stones and recurrent UTIs were prospectively enrolled at four centers. After shared decision-making, participants underwent observation or surgical intervention. The primary outcome was UTI recurrence at 12 months post-enrollment, defined as presence of urinary tract symptoms with positive urine culture. The study was powered to detect a 50% reduction in the rate of UTI recurrence between the groups at 12 months.