Association des Urologues du Québec Congrès Annuel 2026 – Résumés : Session scientifique I

Introduction

Therapeutic strategies to treat prostate cancer (PCa), such as androgen deprivation therapy (ADT), have limited success in PCa management and often lead to obesity.Obese men have a higher risk of developing PCa, which could partially be due to altered composition of intestinal microbiota.Considering that losing excess weight is not easy in aged men, complementary treatment like physical activity (PA) might impede PCa growth; however, whether PA can execute this function under obese conditions (e.g., high-fat diet [HFD]) and the underlying mechanisms are not known.We hypothesize that PA prevents PCa progression under obese conditions by altering lipid, inflammatory cytokines, and intestinal microbiota.Methods: Using NRG mice, we followed the effect of HFD and PA on metabolomics and immunohistochemistry (IHC).Using blood and feces, we monitored metabolites and microbiota changes in response to HFD and PA.We also followed the response to enazalutamide in microfluidic devices and treating MDTs.Results: Our preliminary findings have shown that in mice on HFD, PA does show a trend of reducing tumor growth and a delay in tumor growth.Furthermore, analysis of the fecal samples of the mice showed evolution of the microbiota in response to PA and diets.Analyzing lipid species also revealed lowered levels of diacylglycerol and ceramides in response to PA.