Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Prevalence, predictive factors, and the influential role of physical activity trajectories of cancer-related cognitive impairment among patients newly diagnosed with non-small cell lung cancer
By Ho MH, Vardy JL, Lin YK and 5 others.
Abstract
Purpose
Evidence on the prevalence, trajectory, and predictors of cancer-related cognitive impairment (CRCI) in newly diagnosed non-small cell lung cancer (NSCLC) patients remains limited, particularly regarding the role of physical activity patterns. This study aimed to estimate the prevalence of CRCI, assess changes in objective and subjective cognitive functions, and identify predictors of CRCI, focusing on physical activity trajectories among patients newly diagnosed with NSCLC in Hong Kong.
Methods
A prospective observational study was conducted with 327 NSCLC patients newly diagnosed within 4 weeks. Cognitive function was objectively assessed using the HK-MoCA 5-Minute Protocol and subjectively measured using the FACT-Cog scale at baseline and monthly for six months. Physical activity patterns were analyzed through group-based trajectory modelling. Multivariate logistic regression identified predictors of CRCI, adjusting for demographic and clinical factors.