Anesthesiology research and practice
Perioperative Cerebral Metabolism in Patients Under General Anaesthesia With Sevoflurane or Propofol: Evaluation of the Arterial and Jugular Bulb Metabolome
By Wang C, Ma S, Xing X and 5 others.
Abstract
Objective
Arterial serum was generally used to uncover shifts in the metabolic profile induced by surgery and anaesthesia. The specific perioperative metabolic alterations in the brain remain largely unknown. We aimed to detect perioperative changes in cerebral metabolism by arteriovenous gradients of circulating metabolites across the brain using liquid chromatography-tandem mass spectrometry (LC-MS) analysis.
Methods
The prospective study was conducted at Sichuan Provincial People's Hospital, China. Twenty patients with unilateral pulmonary lesion were recruited. Patients undergoing thoracic surgery were randomised to receive general anaesthesia with sevoflurane or propofol. Blood samples from radial artery and jugular bulb were collected before and after first anaesthetic administration, at the end of 60 min of maintenance of anaesthesia and 60 min after patients regained consciousness. LC-MS-based untargeted metabolomics strategies were used to determine the difference in abundance of circulating metabolites between artery and jugular bulb.