Lupus science & medicine
Systemic Immune-Inflammation Index (SII) correlates with disease activity but not with interferon-associated chemokines in SLE
By Campos-Andaluz DE, Sánchez-Montes R, Barragán-Huerta L and 2 others.
Abstract
Objective
The Systemic Immune-Inflammation Index (SII) is an accessible haematological marker reflecting systemic inflammatory burden. In SLE, type I interferon-associated chemokines have been proposed as biomarkers of disease activity. This study evaluated the discriminatory performance of the SII between patients with SLE and healthy individuals and its correlation with disease activity and circulating interferon-associated chemokines.
Methods
In this cross-sectional study, we analysed data from 95 women with SLE and 1443 healthy female controls from two established cohorts. The SII was calculated as (neutrophil count × platelet count) / lymphocyte count. Disease activity was assessed using the SLE Disease Activity Index 2000 (SLEDAI-2K). Serum levels of CCL11/eotaxin-1, CCL2/MCP-1, CCL5/RANTES, CCL3/MIP-1α, CCL4/MIP-1β, CXCL10/IP-10, CXCL12/SDF-1α, CXCL1/GRO-α and CXCL8/IL-8 were quantified using a multiplex assay.