Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery
Post-neoadjuvant therapy lymph node response in patients with gastric adenocarcinoma
By Ishak G, Corrêa LRDV, Neves TA and 5 others.
Abstract
Background
Neoadjuvant chemotherapy is recommended as the standard of care for eligible patients with locally advanced resectable gastric adenocarcinoma. However, given the often-late diagnosis of this tumor, understanding post-neoadjuvant therapy lymph node involvement remains a determining factor in the prognosis of these patients.
Aims
To evaluate the association between reduced tumor staging after neoadjuvant therapy and lymph node involvement in patients with gastric adenocarcinoma.
Methods
This is a retrospective, analytical, observational study based on the medical records of patients who underwent combination therapy from 2018 to 2024. Pre-treatment clinical staging was performed according to institutional protocol, and the relationship between tumor and lymph node staging was established by comparing the initial clinical staging with the post-treatment pathological staging.