Immunity, inflammation and disease
Nonlinear Correlation Between Prognostic Nutritional Index and Disease Activity of Rheumatoid Arthritis: A Cross-Sectional Study
By Leng L, Tang Q, Li Y and 3 others.
Abstract
Background
The prognostic nutritional index (PNI) is a composite marker reflecting the nutritional and inflammatory status. Its association with disease activity in rheumatoid arthritis (RA) remains incompletely understood. This study aimed to investigate the relationship between PNI and RA disease activity.
Methods
A total of 984 RA patients were enrolled and stratified into three groups according to PNI tertiles. Univariate analysis and linear regression models were performed to evaluate the association between PNI and disease activity scores (DAS28-ESR/DAS28-CRP). A two stage (segmented) linear regression model was used to identify potential inflection points in the relationship.