Clearing the Signal: Serum Prostate-Specific Antigen Trajectories After Transurethral Resection or Open Simple Prostatectomy Versus Tamsulosin–Dutasteride Therapy in Men With Benign Prostatic Enlargement and a Benign Biopsy — A Secondary Analysis of a 12-Week Prospective Cohort

Background and aim: Men with benign prostatic enlargement often have a serum prostate-specific antigen (PSA) above 4 ng/mL, prompting biopsy; when the biopsy is benign, the expected post-treatment PSA fall is uncertain. This study compared 12-week PSA trajectories after transurethral resection of the prostate (TURP) or open simple prostatectomy with those after tamsulosin–dutasteride therapy.

Methods

This secondary analysis used an open, anonymized prospective cohort of 154 men with benign prostatic enlargement, elevated PSA and a benign biopsy from the University of Nigeria Teaching Hospital, Enugu. Total PSA was measured at baseline, 6 and 12 weeks and analysed with mixed analysis of variance, multivariable linear regression and logistic regression.