Clinical and Functional Outcomes of Contemporary Salvage Robotic-Assisted Radical Prostatectomy for Failed Primary Therapy: A Single Institution Review

Background/Objectives: Salvage radical prostatectomy (SRP) is a potentially curative option for recurrent localized prostate cancer after primary radiation or focal therapy, historically limited by technical complexity and poor functional outcomes. This study characterizes contemporary perioperative, oncologic, and functional outcomes of salvage robotic-assisted radical prostatectomy (sRARP) at a single institution over two decades.

Methods

We retrospectively reviewed patients undergoing SRP from 01/01/2004 to 06/30/2026, identified via institutional database queries and natural language processing keyword searches with chart confirmation; analysis was restricted to the robotic-assisted subset. Complications within 90 days were graded by the Clavien–Dindo classification. Biochemical recurrence-free survival (bRFS) required freedom from PSA persistence and recurrence (PSA ≥ 0.2 ng/mL, with biochemical recurrence documented in the medical record) and is reported as a proportion.