Dermatology Practical & Conceptual
Hematological and Inflammatory Markers in Isotretinoin-Associated Sacroiliitis: A Prospective Cohort Study
By Nurcan Metin, Çağrı Turan, Enes KİRİK and 2 others.
Abstract
Introduction
Low back pain (LBP) and sacroiliitis have been reported during isotretinoin therapy, but the role of inflammatory markers in identifying sacroiliitis remains unclear.
Objectives
This study aimed to determine the frequency of LBP and sacroiliitis during isotretinoin therapy and investigate whether any hematological or inflammatory parameter could help identify magnetic resonance imaging (MRI)-confirmed sacroiliitis.
Methods
This prospective cohort study included 220 patients receiving isotretinoin for moderate-to-severe acne. Patients reporting pain at rest or morning stiffness lasting longer than one hour were referred for MRI. Hematological and inflammatory parameters, including C-reactive protein erythrocyte sedimentation neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), monocyte-to–high-density lipoprotein ratio (MHR), red blood cell distribution width (RDW)-to-lymphocyte and RDW-to-platelet ratio, systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI) were compared among patients with MRI-confirmed sacroiliitis, MRI-negative inflammatory LBP, and no LBP.