Reumatologia clinica
Efficacy of tapering biologics and JAK inhibitors in rheumatoid arthritis: A systematic review and meta-analysis
By Rotea-Salvo S, Galindo L, Acasuso-Pardo de Vera B and 7 others.
Abstract
Objective
This study assessed the evidence on the efficacy of tapering anti-TNF, JAK inhibitors, and tocilizumab in patients with rheumatoid arthritis (RA).
Methods
In February 2024, a systematic review was conducted by searching Medline, Embase, Web of Sciences, and the Cochrane Library for randomized controlled trials comparing the efficacy of tapering vs standard treatment. The outcomes evaluated were the maintenance of low disease activity (LDA), remission, and flare-ups. A meta-analysis was conducted when data were available. The risk of bias was assessed using RoB 2. The study was registered on PROSPERO and conducted in accordance with the PRISMA guidelines.