Associations of Preoperative and Early Postoperative Biomarkers with Wound Complications in a Clinically Restricted Surgical Population: A Retrospective Cohort Study

Background/Objectives: Postoperative wound complications remain a clinically important challenge across surgical disciplines, while the contribution of preoperative biological status and the early postoperative systemic response remain incompletely understood. This study aimed to investigate whether routinely available hematological and biochemical biomarkers measured before surgery and during the early postoperative period were associated with postoperative wound complications.

Methods

This retrospective single-center study included 58 patients undergoing surgical treatment for peri-ankle fractures, a clinically relevant setting for investigating postoperative wound complications. Demographic characteristics and routine laboratory parameters obtained within 24 h before surgery and during the first 6 postoperative hours were recorded. Patients were classified according to the presence or absence of postoperative WoC. Univariate analyses, Benjamini–Hochberg false-discovery-rate (FDR) adjustment, receiver operating characteristic (ROC) curve analyses, and separate Firth penalized multivariable logistic regression models for preoperative and early postoperative parameters were performed.