Factors Associated with Delayed Graft Function in a Universal Hypothermic Machine Perfusion Program: A Single-Center Retrospective Cohort Study

Background/Objectives: Hypothermic machine perfusion (HMP) has established itself as an evidence-based and effective preservation strategy to improve graft function and survival after kidney transplantation. It demonstrated a reduction in the incidence of delayed graft function (DGF) compared to static cold storage. However, the risk factors for DGF that persist when HMP is used universally are poorly defined. The aim of this study was to explore donor and recipient factors associated with DGF in a universal HMP kidney transplantation program.

Methods

A single-center retrospective cohort included 134 consecutive deceased-donor kidney transplants (KTs). The primary endpoint was the incidence of DGF. Secondary endpoints included functional results, complications and survival during follow-up. Univariable and multivariable logistic regression models were performed to identify factors associated with DGF. Graft and patient survival were estimated by the Kaplan–Meier method. Graft function was assessed by serum creatinine (Cr) and estimated glomerular filtration rate (eGFR).