Perampanel Attenuates Cognitive and Behavioral Deficits and Modulates Hippocampal Tachykinin Expression in Experimental Temporal Lobe Epilepsy

Background

Epilepsy is one of the most prevalent neurological disorders, often presenting alongside many comorbidities. The present study aimed to evaluate the impact of the antiepileptic drug perampanel (PRM) on cognitive function, depressive-like behavior and the expression of substance P (SP) and neurokinin B (NKB) in the hippocampus of naïve rats and rats with an experimental model of temporal lobe epilepsy (TLE).