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External validation and refinement of the Psychosis Polyrisk Score to detect individuals at clinical high risk for psychosis
By Luis Alameda, Martha E. Shenton, Jai Shah and 22 others.
Abstract
Background
The Psychosis Polyrisk Score (PPS) was developed to characterise exposure to environmental and developmental risk factors for psychosis. In previous studies, the PPS showed promise particularly in discriminating between individuals at clinical high risk for psychosis (CHR-P) and community controls (CC).
Objectives
This study aimed to (1) perform an external validation of the PPS model in a large independent sample and (2) refine the model using expanded predictor data.