European review for medical and pharmacological sciences
Vitamin C for the prevention of complex regional pain syndrome after foot and ankle fractures or surgery: a systematic review
By Carmona-Zamora MT, Garibaldi R, Fiore PI and 2 others.
Abstract
Objective
Complex regional pain syndrome type I (CRPS-I) is a debilitating pain disorder that can develop after trauma or surgery. This systematic review aims to evaluate the association between prophylactic oral vitamin C supplementation and the development of CRPS-I after foot and ankle fractures or surgery.
Materials and methods
This systematic review was conducted according to the PRISMA guidelines. A comprehensive literature search of the PubMed, Embase and Cochrane databases was performed up to the 30th of April 2026. Four studies evaluating vitamin C for the prevention of CRPS-I following foot or ankle fractures or surgeries were therefore included. RoB 2 and NOS were used to evaluate the methodological quality of the studies.