Clinical ophthalmology
Evaluation of the Perimouse Online Suprathreshold Visual Field Test for Glaucoma Screening in a Chinese Population: A Comparison with the Humphrey Field Analyzer
By Shen X, Chen Z, Tan K and 6 others.
Abstract
Purpose
To evaluate the diagnostic performance and spatial agreement of an online suprathreshold perimeter (Perimouse) compared with the Humphrey Field Analyzer (HFA) for detecting glaucomatous visual field defects. Patients and methods: In this prospective comparative study, 174 participants (283 eyes with open-angle glaucoma or healthy controls) underwent Perimouse suprathreshold program and HFA. Abnormal points (missed stimuli in Perimouse; points with P<0.5% on HFA total deviation map) were compared. Diagnostic performance was assessed using receiver operating characteristic (ROC) curve analysis. Point-wise performance used neural network-derived area under the curve (AUC) and Cohen's κ.
Results
Perimouse abnormal-point counts were correlated with HFA abnormal-point counts (r = 0.88, P < 0.001) and negatively correlated with HFA mean deviation (r = -0.80, P < 0.001). The intraclass correlation coefficient for abnormal-point counts between Perimouse and HFA was 0.93, and Bland-Altman analysis showed a mean bias of 0.73 abnormal points, with 95% limits of agreement ranging from -10.70 to 12.17. A cutoff of five abnormal points achieved 85.9% sensitivity and 97.9% specificity (AUC = 0.97), with performance improving with disease severity. Point-wise κ values ranged from 0.32 to 0.78 (AUC, 0.67-0.96). The test duration for Perimouse was 2.64 ± 1.83 minutes.