Drug design, development and therapy
Quadratus Lumborum versus Transversus Abdominis Plane Block with Oxycodone or Sufentanil for Recovery Quality After Laparoscopic Gastrointestinal Cancer Surgery: A Factorial Randomized Trial
By Yang GW, Song XY, Yang YF and 3 others.
Abstract
Purpose
Quadratus lumborum block (QLB) theoretically provides broader visceral analgesia than transversus abdominis plane block (TAPB), while oxycodone, a dual μ- and κ-opioid receptor agonist, may offer superior visceral pain control compared with sufentanil. We evaluated these two regional techniques and two opioid regimens simultaneously in a factorial design to determine their effects on recovery after laparoscopic gastrointestinal cancer surgery.
Methods
In this single-center, randomized, 2×2 factorial trial, 120 adults were randomly assigned to bilateral QLB or TAPB (0.375% ropivacaine 20 mL per side) and oxycodone or sufentanil patient-controlled analgesia. All patients received intraoperative dexmedetomidine and flurbiprofen axetil. The primary outcome was 24-h recovery quality (15-item quality of recovery scale; minimal clinically important difference 6 points). Secondary outcomes included recovery quality at 48 and 72 h, visceral and incisional pain, opioid consumption, rescue analgesia, and adverse events.