JMIR aging
Impact of Chatbot-Based Cognitive Training on Cognitive Function and White Matter Integrity in Cognitively Unimpaired Older Adults: Randomized Controlled Trial
By Kim BR, Kim E, Lim SM and 3 others.
Abstract
Background
Cognitive training may enhance cognition and support brain health during aging, but few trials have evaluated readily accessible chatbot-based programs with neuroimaging outcomes.
Objective
This study aimed to evaluate the effects of a chatbot-based cognitive training program on white matter microstructural organization and cognition in cognitively unimpaired older adults.
Methods
In a single-blind randomized controlled trial, 72 cognitively unimpaired older adults were assigned to chatbot-based cognitive training (30 min/day, 5 days/week for 12 weeks; n=37) or a no-intervention control (n=35). Diffusion tensor imaging at baseline and 12 weeks quantified fractional anisotropy (FA) in predefined white matter tracts, and cognition was assessed with the Cambridge Neuropsychological Test Automated Battery.