Breast cancer
Predictive Value of Combined Ultrasound Viscoelasticity Imaging, CEUS, AAPR, and PLR for Assessing Neoadjuvant Chemotherapy Efficacy in Breast Cancer
By Li M and Shi J.
Abstract
Background
The present study addresses the clinical demand for reliable prediction of neoadjuvant chemotherapy (NAC) efficacy in breast cancer and seeks to overcome the limitations of conventional approaches (such as imaging and pathology), including limited sensitivity, invasiveness, and delayed assessment. The clinical utility of viscoelasticity imaging, contrast-enhanced ultrasound (CEUS), and peripheral blood inflammatory markers (AAPR, PLR) for early and accurate prediction of NAC efficacy was evaluated using a multimodal strategy.
Methods
A retrospective cohort study was conducted, including 105 patients with locally advanced breast cancer. According to Miller-Payne pathological grading, patients were classified into a major histologically response group (MHR) and a non-major histologically response group (NMHR). Prior to NAC, viscoelastic parameters (eg, Emax, Vmax) and CEUS parameters (e.g. PI, TTP, MTT) were obtained by ultrasound examination, and peripheral blood inflammatory markers were collected. Predictive performance was analyzed using multivariate logistic regression and ROC curve analysis.