Pharmaceuticals
Comparative Effects of IL-17 and IL-23 Inhibitors on Lipid Profiles and Lipid-Derived Atherogenic Indices in Patients with Psoriasis
By Celik C, Çelik MS and Cepik N.
Abstract
Background
Psoriasis is associated with increased cardiovascular risk and altered lipid metabolism. The comparative effects of IL-17 and IL-23 inhibitors on lipid-derived atherogenic indices remain unclear.
Objective
To compare the effects of IL-17 and IL-23 inhibitors on lipid parameters and lipid-derived atherogenic indices in patients with psoriasis.
Methods
In this retrospective cohort study, 152 patients were assessed for eligibility, and 108 were included: 51 receiving IL-23 inhibitors and 57 receiving IL-17 inhibitors. Lipid parameters, lipid-derived indices, and PASI were evaluated at baseline and after 12 months.