Nutrients
Association Between Eating Disorders and Subsequently Recorded Depression and Bipolar Disorder: A Retrospective Cohort Study
By Hadar V, Ulambayar B, Nagy AC and 1 others.
Abstract
Background/objectives
Mental health is strongly affected by eating disorders, yet there are few longitudinal studies that have examined their association with subsequently recorded mood disorders. The present study aimed to investigate the association between exposure to eating disorders and first recorded diagnoses of depression and bipolar disorder during follow-up.
Methods
This retrospective cohort study was based on the hospital database of the Clinical Center of the University of Debrecen, covering the period between 2007 and 2022. The dataset included 333,807 patients and 805,989 hospital records. Diagnoses were identified using physician-recorded ICD-10 codes. Eating disorders were defined as the exposure variable, while first recorded diagnoses of depression and bipolar disorder during follow-up were treated as outcomes. Patients with the relevant mood disorder recorded in their entry year were excluded from the corresponding analysis. Associations were evaluated using survival analysis to estimate hazard ratios (aHRs) and 95% confidence intervals (CIs).