Integrative Multi-Database Bioinformatics Characterization of FANCE in Hepatocellular Carcinoma: Prognostic, Epigenetic, Immune, and ncRNA Associations

Background and Objectives: The Fanconi anemia complementation group E (FANCE) is a protein component of the Fanconi anemia (FA) DNA repair complex and contributes to genome integrity. However, its molecular and clinical relevance in liver hepatocellular carcinoma (LIHC) remains incompletely understood. This study characterized the FANCE expression, prognosis, epigenetics, immune responses, noncoding RNA (ncRNA) networks, and other related molecular processes in LIHC. Materials and Methods: An integrative multi-database bioinformatics analysis was conducted using public databases and web-based platforms. FANCE expression, DNA methylation, co-expression profiles, and functional enrichment; immune cell infiltration; miRNA-ncRNA, chemical-gene, and protein-protein interactions; treatment response; and survival were evaluated.