Biomedicines
Histopathological Remodeling and Reduced Hypoxia-Related Marker Expression Following Marsupialization of Ameloblastoma: A Paired Analysis
By Ishida S, Takabatake K, Arashima T and 7 others.
Abstract
Background
Marsupialization is widely used as a jaw-preserving treatment for large cystic ameloblastomas and is generally believed to reduce tumor volume through decompression. However, the biological mechanisms underlying tumor regression remain poorly understood. This study aimed to investigate the histopathological and hypoxia-related molecular changes in ameloblastoma before and after marsupialization using paired specimens from the same patients.
Methods
This retrospective paired study included 13 patients with ameloblastoma who underwent marsupialization (median duration, 3 months; range, 1-12 months) followed by enucleation with peripheral ostectomy. Histopathological and immunohistochemical changes were compared between paired pre- and post-marsupialization specimens obtained from the same patients. Expression of the hypoxia-related molecules HIF-1α, carbonic anhydrase IX (CA IX), glucose transporter 1 (GLUT1), vascular endothelial growth factor (VEGF), and the proliferation marker Ki-67 was evaluated.