The Neuroprotective Properties of Shogaol-Enriched Ginger Extract (SEGE) Mitigate Synaptic, Cholinergic, and Metabolic Brain Dysfunction in a Mouse Model of Metals and High-Fat-Diet-Induced Neuropathology

Background/Objective: Co-exposure to heavy metals from environment and a high-fat diet (HFD) represents a growing health concern, contributing to various diseases, but their combined effects on brain health remain less explored. This study aimed to evaluate the neuroprotective potential of Shogaol-enriched ginger extract (SEGE) against heavy metals- and HFD-induced neuropathology. Plant-derived isolated pure compounds can be costly and less accessible; SEGE may offer a translatable, multi-target dietary intervention.