Antibiotics
Multidrug Resistance, Antimicrobial Therapy, and In-Hospital Mortality in Patients with Healthcare-Associated Infections: A Retrospective Cohort Study
By Voidazan S, Bodea R, Moraru L and 3 others.
Abstract
Background
Healthcare-associated infections (HAIs), particularly those caused by antimicrobial-resistant pathogens, remain an important cause of adverse outcomes among hospitalized patients. The combined contribution of antimicrobial resistance, clinical characteristics, and antimicrobial treatment to mortality requires further evaluation. This study aimed to investigate factors associated with in-hospital mortality among patients with HAIs, with particular emphasis on multidrug resistance (MDR) and post-culture antimicrobial treatment.
Methods
We conducted a retrospective observational cohort study that included 192 patients with 242 documented HAI episodes in a hospital in Târgu-Mureș, Romania. Demographic and clinical characteristics, invasive procedures, microbiological findings, antimicrobial resistance phenotypes, antimicrobial exposure, and in-hospital outcome were evaluated. Comparisons between survivors and non-survivors were performed using the Mann-Whitney U test, Pearson's chi-square test, or Fisher's exact test, as appropriate. Factors associated with in-hospital mortality were investigated using univariable and multivariable logistic regression.