Journal of Korean medical science
Clinical Characteristics of End-Organ Failure as a Cause of Primary Amenorrhea: Multicenter Study in Korean Population
By Chung YS, Yun BH, Kim HJ and 7 others.
Abstract
Background
Primary amenorrhea is defined as the absence of menstruation by the age of 13 years in the absence of secondary sexual characteristics or by age 15 in the presence of normal secondary sexual development. It has multiple potential causes, and accurate diagnosis is crucial for effective treatment. This study aimed to provide insights into the incidence and distribution of primary amenorrhea due to congenital anomalies or disorders of sexual development (DSD) in Korea.
Methods
A retrospective multicenter cohort study was conducted, analyzing data from January 2001 to December 2016. Patient history, clinical characteristics, and management approaches for primary amenorrhea were compared based on the underlying causes. The DSD group included individuals with XX DSD, XY DSD, and sex chromosome DSD. The Müllerian agenesis group consisted of 7 different types of anomalies: Mayer-Rokitansky-Küster-Hauser syndrome, uterine agenesis, cervical agenesis, cervicovaginal agenesis, vaginal agenesis, transverse vaginal septum, and imperforate hymen.