Clinical ophthalmology
Magnitude of Visual Recovery at 12 Months After Optic Neuritis: Beyond Visual Acuity in a Thai Tertiary-Care Cohort
By Pattanapattana M, Kulniwatcharoen P and Hansapinyo L.
Abstract
Purpose
To compare the magnitude of visual recovery at 12 months after optic neuritis (ON), with long-term change as a secondary outcome, and distinguish numerical improvement from attained visual acuity (VA). Patients and methods: This retrospective cohort included 184 adults with idiopathic ON, AQP4-IgG-positive NMOSD-ON, MOGAD-ON, or MS-ON. One affected eye per patient was selected by worse baseline VA, with right-eye ties. Primary recovery was baseline minus 12 ± 3-month logMAR VA; secondary recovery used last-follow-up VA. Baseline-adjusted VA contextualized change scores. MOGAD was descriptive only.
Results
Twelve-month VA was available in 153 patients. Mean improvement was 0.76, 0.80, and 1.10 logMAR in idiopathic ON, NMOSD-ON, and MS-ON, respectively (ANOVA P=0.406). Corresponding last-follow-up changes were 0.78, 0.71, and 0.89 logMAR, over median follow-up of 38, 52, and 82 months. The baseline-adjusted 12-month analysis included 150 patients. Early steroid initiation was associated with better attained VA (β=-0.45; 95% CI -0.77 to -0.14; P=0.005).