Open access rheumatology : research and reviews
Clinical and Immunological Factors Associated with Disease Activity in MPO-ANCA-Associated Vasculitis
By Chen Y and Shuai Z.
Abstract
Objective
To explore clinical and immunological factors associated with disease activity in myeloperoxidase‑antineutrophil cytoplasmic antibody‑associated vasculitis (MPO‑AAV), and analyze cross‑sectional correlations of renal impairment, anemia and antinuclear antibodies (ANA) with disease activity.
Methods
In this retrospective study, 82 consecutive hospitalized MPO‑AAV patients (September 2023‑February 2025) were stratified into high‑ and low‑activity groups using BVAS‑3 (cut‑off >15 points). Baseline clinical and laboratory data were compared. Spearman correlation and univariate‑multivariate logistic regression were applied to evaluate correlates of high disease activity.