Chronic diseases and translational medicine
GelMA-Based Hydrogel Encapsulating Astragalus Polysaccharides and Umbilical Cord Mesenchymal Stem Cell Exosomes Promotes Full-Thickness Skin Wound Healing
By Tian J, Zhao X, Xie J and 5 others.
Abstract
Background
Wound healing involves excessive oxidative stress and cellular dysfunction, while current single therapies remain inadequate. Astragalus polysaccharides (APS) and exosomes (Exos) possess antioxidative and regenerative properties, and gelatin methacryloyl (GelMA) hydrogel provides a biocompatible platform for localized delivery. Here, we developed an APS-Exos@GelMA hydrogel to promote wound repair.
Methods
The biological effects of APS and Exos were assessed through in vitro cellular assays, while the physicochemical properties and biocompatibility of APS-Exos@GelMA were characterized. Its therapeutic efficacy was further evaluated in a full-thickness skin defect model through macroscopic observation and histological analysis.