Fluids and barriers of the CNS
Ascorbic acid transport via choroid plexus measured with 6-deoxy-6-[18F]fluoro-L-ascorbic acid PET
By Zhang Y, Lin X, Deng H and 9 others.
Abstract
Background
Ascorbic acid, a crucial antioxidant, is transported from blood to cerebrospinal fluid (CSF) via the choroid plexus (ChP). A noninvasive tool to visualize and quantify ascorbic acid transport process in the human brain is currently lacking. We aimed to determine whether 6-deoxy-6-[18F]fluoro-L-ascorbic acid ([18F]FAA) PET can visualize and quantify ascorbic acid transport from blood to CSF via the ChP in humans.
Methods
This prospective secondary analysis evaluated participants between May 2024 and September 2024. Eight participants underwent a 45-minute dynamic brain [18F]FAA PET/CT scan; 153 participants underwent a static [18F]FAA PET/CT scan. Tracer accumulation in ChP and CSF were measured in the lateral and fourth ventricles. Univariable and multivariable linear regression models were used to investigate the associated factors of [18F]FAA PET metrics.