Neurology international
Subjective Sleep Quality in Relation to Relapse Status in Relapsing-Remitting Multiple Sclerosis: A Propensity Score-Matched Nested Case-Control Analysis
By Taskov D, Ivanova S, Antova I and 4 others.
Abstract
Background
Sleep disturbance is common in multiple sclerosis (MS), but its relationship with relapse status remains insufficiently defined. This study examined whether poorer subjective sleep quality was associated with relapse status in patients with relapsing-remitting multiple sclerosis.
Methods
This propensity score-matched nested case-control analysis included 132 patients with relapsing-remitting MS selected from 473 consecutively evaluated patients at a tertiary multiple sclerosis centre. Patients in relapse were matched 1:1 to patients in remission by age, sex, disease duration, Expanded Disability Status Scale score, disease-modifying therapy duration and efficacy class, and relapse in the previous year. Sleep quality and related symptoms were assessed using validated questionnaires.