Neurology international
Clinical Phenotypes, Neuroimaging, and Outcomes in Prolonged and Persistent Non-Motor Migraine Aura: A Systematic Review and Episode-Level Synthesis
By Meiramova A, Ainabekova B, Tursynbet Y and 1 others.
Abstract
Background/objectives
Prolonged and persistent migraine aura may mimic cerebral ischemia, but its clinical course and neuroimaging features are poorly characterized. We synthesized episode-level evidence on non-motor aura lasting more than 60 min without reported established infarction.
Methods
This systematic review (International Prospective Register of Systematic Reviews [PROSPERO] CRD420261461238) followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. PubMed, Scopus, and Google Scholar were searched from inception to August 2026 and the searches were rerun with an extended strategy on 5 October 2026, supplemented by backward and forward citation searching. Eligible reports provided individual-episode clinical data and temporally related neuroimaging. Owing to publication selection, heterogeneous reporting, and clustering, the synthesis was descriptive.