Current oncology
Cancer-Specific Survival in Octogenarian Breast Cancer Patients: A Competing Risk Analysis of Prognostic Factors
By Mermut Ö, Yalçın B, Gürsu RU and 5 others.
Abstract
Background
This study evaluated long-term survival outcomes in breast cancer patients aged ≥80 years, focusing on how prognostic factors change when competing mortality risks are considered.
Methods
We retrospectively analyzed 106 octogenarian breast cancer patients treated between 2013 and 2023. Endocrine therapy was evaluated as a treatment-related prognostic factor. Treatment-related prognostic factors were evaluated using multivariable Cox proportional hazards and Fine-Gray competing-risks models.
Results
The median age was 82 years, and the median follow-up time was 27.5 months (range, 6-99 months). In the multivariable Cox proportional hazards, biopsy compared with surgery (HR, 0.56; p = 0.037), presence of endocrine therapy (HR, 0.38; p = 0.003), and CCI ≥ 8 (HR, 9.96; p < 0.001) were independently associated with OS. In the Fine-Gray model, the associations of surgical procedure (p = 0.120) and endocrine therapy (p = 0.081) with breast cancer-specific mortality were no longer statistically significant. CCI ≥ 8 remained significantly associated with breast cancer-specific mortality (sHR, 3.76; 95% CI, 1.52-9.31; p = 0.004).