Advances in respiratory medicine
Stroke Lesion Location Is Associated with Dynamic Inspiratory Performance: A Cross-Sectional Study
By Kuo HC, Liu G, Zhong Z and 3 others.
Abstract
Background/objectives
We examined whether respiratory performance differed among broad stroke lesion-location categories.
Methods
This exploratory single-center cross-sectional analysis combined pre-intervention assessments from 20 participants in an earlier trial with 60 subsequently recruited participants. The 80 patients were classified into frontal lobe (n = 27), basal ganglia region (n = 26), or brainstem (n = 27) categories. Peak inspiratory flow (PIF), strength index (S-Index), and five conventional respiratory outcomes were assessed. Holm correction was applied across seven outcomes. Linear models used type 3 heteroscedasticity-consistent (HC3) robust standard errors and the original six clinical covariates. Additional PIF analyses incorporated time since stroke, National Institutes of Health Stroke Scale (NIHSS), or modified Barthel Index (MBI), and restricted the sample to ischemic or first-ever stroke.