TheScientificWorldJournal
Comparative Quality Evaluation of Marketed Cefixime Trihydrate Tablet Brands Available in Bangladesh
By Islam A, Shanto SA, Akter S and 6 others.
Abstract
Aims
In low- and middle-income countries, antibiotic resistance is rising rapidly because of poor medication adherence, polypharmacy, and weak regulatory enforcement, while substandard and counterfeit medicines further accelerate resistance. Cefixime trihydrate, a broad-spectrum third-generation cephalosporin, is a widely used and frequently prescribed antibiotic in Bangladesh. This study evaluated quality attributes, including % drug content and % drug release, of eight commonly prescribed cefixime 200 mg tablet brands and compared them with the innovator-equivalent brand.
Methods
Chromatographic separation was performed on a reversed-phase C18 column with UV detection at 282 nm (column temperature 30°C; run time 8 min), using methanol and 0.01 M KH2PO4 buffer (pH 4.5) at 1 mL/min. Dissolution studies were conducted using a USP Apparatus 2, and antimicrobial activity was assessed via the Kirby-Bauer disc diffusion method.