MicroRNA-34b-5p Modulates Sepsis-Induced Acute Kidney Injury via the LMX1B/HIGD1A Axis: Implications for Molecular Therapeutics

Background

Sepsis-induced acute kidney injury (AKI) represents a critical complication with high mortality, largely due to the absence of specific targeted treatments MicroRNAs (miRNAs) are emerging as critical regulators in AKI pathogenesis, but their specific molecular mechanisms and biotechnological applications remain unclear.

Objectives

This research sought to clarify the functional significance of miR-34b-5p and its regulatory mechanism involving the LMX1B/HIGD1A signaling axis in sepsis-induced acute kidney injury (AKI), while also investigating its potential as a novel biotechnological therapeutic target.

Materials and methods