BMC infectious diseases
Azithromycin versus ceftriaxone for uncomplicated typhoid fever in children: a systematic review and meta-analysis of randomized controlled trials
By Manzoor MU, Anwar A, Owais M and 5 others.
Abstract
Background
Typhoid fever caused by Salmonella enterica serovar Typhi remains a major cause of febrile illness among children in low- and middle-income countries, particularly in South and Southeast Asia. The increasing emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains has substantially limited available treatment options and highlighted the need for effective oral therapies. Azithromycin and ceftriaxone are commonly used for uncomplicated typhoid fever in children; however, evidence comparing their efficacy and safety remains limited.
Objective
To compare the efficacy and safety of azithromycin versus ceftriaxone for the treatment of uncomplicated typhoid fever in children through a systematic review and meta-analysis of randomized controlled trials.