Muscles
Creatine Supplementation in Crohn's Disease: Possible Therapeutic Trends in Symptoms and Muscle Tissue Integrity
By Papadimitriou K, Kreider RB, Deligiannidou GE and 2 others.
Abstract
Background/objectives
Creatine (Cr) supplementation may serve as a nutritional intervention, enhancing gut metabolism and preserving lean body mass, specifically fat-free mass, thereby improving functional capacity and quality of life in individuals with Crohn's disease (CD). This paper aims to explore the potential mechanisms through which Cr supplementation may influence CD patients and review the current literature on this topic.
Results
Studies were analyzed to assess the relationship between Cr supplementation and CD. Preliminary evidence suggests potential therapeutic benefits, although data remain limited.
Discussion
Cr supplementation warrants further investigation through clinical trials and cohort studies. Emerging data from both in vitro and in vivo models indicate creatine monohydrate (CrM) may constitute a biologically reasonable supportive strategy, requiring formal evaluation in clinical trials in patients with CD.