Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia
Association between triglyceride-glucose index (TyG) as a surrogate marker of insulin resistance and risk of gestational diabetes mellitus (GDM): updated systematic review and meta-analysis
By Vásquez-Tirado GA, Moncada-Gutiérrez DA, Farfán-Castillo A and 5 others.
Abstract
Objective
This systematic review and meta-analysis evaluated whether the first-trimester triglyceride-glucose (TyG) index predicts subsequent gestational diabetes mellitus (GDM).
Methods
MEDLINE/PubMed, Scopus, Embase, Web of Science, ScienceDirect, and the Cochrane Library were searched from inception to August 12, 2025. Eligible studies were prospective or retrospective cohorts including adult women with singleton pregnancies, first-trimester TyG assessment, and later GDM ascertainment; non-original studies, case reports/series, and duplicates were excluded. Risk of bias was assessed using ROBINS-E. Adjusted odds ratios (ORs) were pooled using random-effects models with REML and Hartung-Knapp adjustment. Sensitivity, subgroup, diagnostic accuracy, publication-bias, and GRADE certainty analyses were performed.