Case reports in perinatal medicine
Late-onset spontaneous chorioamniotic membrane separation mimicking amniotic band sequence with rapid progression to preterm premature rupture of membranes
By Terece C, Keçecioğlu TS, Yozgat ST and 1 others.
Abstract
Objectives
Spontaneous chorioamniotic membrane separation (CMS) diagnosed in the third trimester is rare, and its short-term clinical course remains poorly characterized. We report a case of late-onset CMS with rapid progression to preterm premature rupture of membranes (PPROM).
Case presentation
A 23-year-old woman with a prior cesarean delivery was referred at 35 weeks for suspected fetal macrosomia. At 36+4 weeks, ultrasonography revealed freely mobile, multilayered membranes adjacent to the fetal extremities and umbilical cord, raising concern for amniotic band sequence. Detailed anatomical assessment and color Doppler evaluation demonstrated intact extremities and preserved distal perfusion, supporting a diagnosis of CMS. The patient was admitted for surveillance, and PPROM occurred within hours of diagnosis. Cesarean delivery resulted in a live male infant weighing 4,170 g (Apgar scores 8/9). Intraoperative findings confirmed near-complete amnion-chorion separation.