Journal of dental sciences
A bibliometric evolution of molecular mechanisms and emerging research trends of therapeutic resistance in oral cancer
By Chien CY, Chen YC, Wu JR and 3 others.
Abstract
Background/purpose
Drug resistance has served as a primary determinant of treatment failure and disease recurrence in oral cancer. The present study aimed to evaluate the global research landscape of drug resistance mechanisms in oral cancer by integrating bibliometric mapping with bioinformatic validation.
Materials and methods
A comprehensive dataset of 1660 publications was retrieved from the Scopus database. Bibliometric analyses were performed using Biblioshiny and VOSviewer to evaluate publication trends, collaborative networks, and thematic evolution. To bridge research trends with biological mechanisms, 1469 genes associated with oral cancer and drug resistance were extracted from the GeneCards database and subjected to functional enrichment and canonical pathway analysis via Ingenuity Pathway Analysis (IPA).