Journal of dental sciences
Anemia, hematinic deficiencies, and hyperhomocysteinemia in gastric parietal cell antibody-positive and -negative recurrent aphthous stomatitis patients
By Wu YH, Wang YP, Lee YP and 3 others.
Abstract
Background/purpose
Our previous study found the serum gastric parietal cell antibody (GPCA) positivity in 12.8% of 430 recurrent aphthous stomatitis (RAS) patients. This study assessed whether GPCA-positive RAS (GPCA+RAS) patients had significantly higher frequencies of macrocytosis, anemia, hematinic deficiencies, and hyperhomocysteinemia than healthy control subjects or GPCA-negative RAS (GPCA-RAS) patients.
Materials and methods
The mean corpuscular volume, blood hemoglobin (Hb), and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels were measured and compared between any two of three groups of 55 GPCA+RAS patients, 375 GPCA-RAS patients, and 430 healthy control subjects.