Journal of dental sciences
Heat shock factor 1 promotes cell migration and predicts poor prognosis in oral squamous cell carcinoma
By Wu FY, Ko HH, Lin WR and 1 others.
Abstract
Background/purpose
Heat shock factor 1 (HSF1) regulates heat shock proteins and stress-responsive genes and has been implicated in tumor progression and poor prognosis in several malignancies. However, the clinicopathological significance and biological role of HSF1 in oral squamous cell carcinoma (OSCC) remain unclear. This study investigated HSF1 expression in OSCC tissues, its association with clinicopathological parameters and survival, and its functional role in OSCC cell migration.
Materials and methods
HSF1 expression was evaluated by immunohistochemical staining in 80 OSCC specimens and 20 normal oral mucosa samples. HSF1 immunoreactivity was quantified using the labeling index (LI). Associations between HSF1 LI and clinicopathological parameters were analyzed. Kaplan-Meier survival analysis and Cox proportional hazards regression were performed. The effect of HSF1 downregulation on OSCC cell migration was examined in vitro.