Journal of dental sciences
Anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in recurrent aphthous stomatitis patients with vitamin B12 deficiency
By Wang YP, Lee YP, Wu YH and 3 others.
Abstract
Background/purpose
Our previous study found that 30 of 430 recurrent aphthous stomatitis (RAS) patients have vitamin B12 deficiency. This study assessed whether the vitamin B12-deficient RAS (B12D/RAS) patients had significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than healthy control subjects and evaluated whether all B12D/RAS patients had pernicious anemia (PA).
Materials and methods
The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 430 RAS patients including 30 B12D/RAS patients and 430 healthy control subjects were measured and compared.