Journal of dental sciences
Hollow fiber assay microtube array membrane (MTAM-HFA) for personalized anticancer drug screening in selection of concurrent chemoradiotherapy in oral squamous cell carcinoma
By Chou SJ, Hsu PC, Chew CH and 7 others.
Abstract
Background/purpose
In Asia, oral squamous cell carcinoma (OSCC) are on the rise in part due to the consumption of betel nut in several regions. This clinical case study evaluated the application of the microtube array membrane-hollow fiber assay (MTAM-HFA) that was previously clinically demonstrated in the context of the selection of chemotheraputic agents as part of the treatment of concurrent chemoradiotherapy (CCRT) in OSCC.
Materials and methods
In this double-blind cohort study, surgical samples from OSCC patients were retrieved and sent for screening of tumor response against a panel of chemotherapeutic agents (5-fluorouracil (5-FU), cisplatin, carboplatin and docetaxel). Screening outcomes were compared to the clinical outcome of patients receiving the same agents.