Journal of dental sciences
Prognostic impact of the preoperative Naples prognostic score on overall and progression-free survival in surgically treated oral squamous cell carcinoma: A retrospective cohort study from a Taiwanese medical center
By Hsueh PL, Li YH, Yang CY and 3 others.
Abstract
Background/purpose
Systemic inflammation and nutritional status are key determinants of cancer progression and survival. The Naples prognostic score (NPS), integrating nutritional and inflammatory biomarkers, has shown prognostic value in cancers, however its significance in oral squamous cell carcinoma (OSCC) remains unclear. This study evaluated the prognostic value of NPS in patients with OSCC undergoing curative surgery.
Materials and methods
This retrospective cohort study included 334 patients with OSCC who underwent surgery at a Taiwanese medical center between 2002 and 2015. Preoperative serum albumin, total cholesterol, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio were used to calculate NPS. Patients were categorized into three groups: Group 0 (score=0), Group 1 (score = 1-2), and Group 2 (score = 3-4). Five-year overall survival (OS) and progression-free survival (PFS) were analyzed using Kaplan-Meier methods and log-rank tests. Multivariate Cox proportional hazards regression was performed to identify independent prognostic factors.